Gel and Tablets
Regulator and stimulant for dermal depigmentation
Research progress in the field of skin depigmentation
Numerous recent studies have pinpointed certain anomalies in patients with skin depigmentation.
These include a gradual loss of melanocytes and an abnormally high level of hydrogen peroxide (H2O2) in the epidermis, leading to oxidative stress and oxidation of proteins and lipids.
Oxidative stress and depigmentation
Oxidative stress damages the melanocyte membranes, the cells which are essential for skin pigmentation.
In patients with vitiligo, it has been shown that a deficiency in catalase, vitamins and minerals is one of the causes of oxidative stress.
Restoring the physiological conditions for pigmentation
- It has been shown that treatment with pseudocatalase limits oxidative stress and hence damage to the melanocytes which are responsible for skin pigmentation.
- Topical or systemic administration of gingko biloba, antioxidants such as vitamin E and superoxide dismutase (SOD), can limit depigmentation and even, according to some studies, promote repigmentation, ideally in combination with phototherapy.
- Vitamins and minerals (B12, E, selenium, calcium, folic acid) help to compensate for deficiencies in vitiligo patients.
Cell damage in vitiligo patients
- Disturbance in phenylalanine hydroxylase activity during an anomaly in the biopterin cycle / 6-BH4.Epidermal H2O2 accumulation alters the tetrahydrobiopterin (6-BH4) cycle, which is recognised for its importance during the initial stages of melanin and catecholamine synthesis, which are accompanied by a fall in catalase levels. A supply of calcium and catalase reduces the level of H2O2 and regulates the biopterin cycle.
- Tyrosinase is a crucial enzyme in the process of melanogenesis which ensures skin pigmentation. Tyrosinase is inhibited in the presence of free oxygen radicals (superoxide ion O2-). A supply of catalase, SOD and ginkgo biloba reduces levels of H2O2 and O2-.
- Melanin whitens in the presence of oxygen radicals (.OH). A supply of catalase, SOD and ginkgo biloba helps to reduce levels of .OH.
VitiDerm gel and tablets
VitiDerm was developed by doctors P. Lemoine, Phounsavath, E. Steinheimer, Selosse & Debavelaere on the basis of in-depth research and tests.
Formulated with an optimum combination of ingredients whose benefits have been demonstrated by numerous scientific studies, VitiDerm delivers a concentrated cocktail of high-performing active substances:
- Vegetable-based melon extract: rich in anti-oxidising agents (superoxede dismutase - SOD and catalase), helps restore normal physiological conditions in terms of free radicals at the keratinocyte and melanocyte level.
- Ginkgo Biloba: an antiradical, like melon, to combat the free radicals which cause damage to cells and melanocytes.
- Vitamin D3 (calcium chloride) helps preserve the cell membrane structure and contributes to the production of melanin
- L-Cystine an amino acid with antioxidant properties which is involved in the synthesis of melanin.
- Zinc, copper, selenium, folic acid, vitamins C and B12 to compensate for the deficiencies typically found in persons with skin depigmentation.
- Vitamin E limits oxidation of the melanocyte membranes.